Lipids in estimation of tuberculosis treatment various modes toxic action at the patients with hiv-infection

Абстракт

Russian Federation concerns to number of the countries with high worsening tuberculosis epidemiological situation on HIV-infection. At the patients with HIV-infection of tuberculosis mortality reaches 43-89 %. The tuberculosis morbility at the patients with HIV-infection were at 21-37 of time is higher, than at the people without HIV-infection, and in separate researches speak about risk of tuberculosis development at early stages of HIV-infection in 113 times. The purpose of work - to determine importance of blood lipid changes in an estimation of toxic action of various modes of tuberculosis treatment at the patients with HIV-infection. Totally 100 persons with a tuberculosis and HIV infection with a various mode of tuberculosis treatment were surveyed. The parameters of the routine biochemical tests and relative contents total lipids and phospholipids were investigated. The analysis of biochemical tests routine parameters has found out absence of level increase total bilirubint, creatinine, alaninaminotransferase (АLT), aspartasaminitransfarase (AST) activity. However there is increased level of activity alkaline phosphotase (173,2 ЕД/л) and lactatedehydrogenese (379,4 ЕД/л) at the patients with the first mode tuberculosis chemotherapy. The first standard mode of tuberculosis treatment was rendered more expressed toxic effect on the patients, which was shown more by high level fry fatty acid, trigliceriges and low level of free cholesterol and ethers of cholesterol were established. The increase of a phosphstidiletanolamine level can be considered as not only the proved marker of the first standard regime toxic tuberculosis treatment action, but also efficiency of application antiretroviral therapy at the patients with tuberculosis/HIV-infection